What is the maximum safe dose of prilocaine 3% for this 75kg patient?
Pharmacology questions in the ADC written exam test applied prescribing decisions, not rote recall of drug names. This exam-level vignette tests your ability to work through clinical details and arrive at the correct management.
Dimitrios Papadopoulos, a 61-year-old Greek-Australian man, presents to your dental practice for multiple posterior restorations. He has a history of unstable angina (recent chest pain episodes), type 2 diabetes mellitus, and glucose-6-phosphate dehydrogenase (G6PD) deficiency. His medications include metformin, aspirin, and sublingual GTN. He weighs 75kg. You plan extensive treatment requiring significant local anaesthesia. His cardiologist has advised avoiding adrenaline-containing preparations due to his cardiac condition. What is the maximum safe dose of prilocaine 3% for this 75kg patient?
- A. 675mg (22.5mL)
- B. 600mg (20mL)
- C. 300mg (10mL)
- D. 450mg (15mL)
- E. 525mg (17.5mL)
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Show the answer and cited explanation
According to TG Table 13.9, maximum mg/kg dose of prilocaine 3% is 9mg/kg. For 75kg: 75 × 9 = 675mg. Converting to volume: 675mg ÷ 30mg/mL = 22.5mL.
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